Wang, Y. et al. Identification of YTH domain-containing proteins as the readers for Chen, Z. et al.


BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. Kato, M. et al. Recent advances in RNA sequencing technology have revealed hundreds of different modifications which, by influencing RNA stability, can control gene expression. Singh, R. & Reddy, R. Gamma-monomethyl phosphate: a cap structure in spliceosomal U6 small nuclear RNA. Schremmer B, Manevich Y, Feinstein SI, Fisher AB. RNA is a critical component of every single living cell in the universe.

Li, X. et al. Internet Explorer). D’Orazio, K. N. et al. & Wagner, J. R. DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. 5-Methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Shoshan, E. et al. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer.

Lu, W. et al. Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs. Human ADAR1 prevents endogenous RNA from triggering translational shutdown. Acetylation of cytidine in mRNA promotes translation efficiency. Role of pre-mRNA splicing in plant development. Sign up for the Get the most important science stories of the day, free in your inbox. A non-coding RNA localized in the nucleolus and part of ribonucleoprotein complexes involved in the modification of ribosomal RNA precursors and transfer RNAs.(pre-miRNA). The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5’-3’ exoribonuclease XRN1. Wetzel, C. & Limbach, P. A. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Identification of the m(6)Am methyltransferase PCIF1 reveals the location and functions of m(6)Am in the transcriptome. Primary transcript from which one or several microRNAs originate. Györffy B, Lanczky A, Eklund AC, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites. Reijns, M. A., Alexander, R. D., Spiller, M. P. & Beggs, J. D. A role for Q/N-rich aggregation-prone regions in P-body localization. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. T.K. Ping, X. L. et al. Shi, H. et al. Reversible methylation of m6Am in the 5′ cap controls mRNA stability. Liu, J. et al. & Chan, S.-H. mRNA capping: biological functions and applications. Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. Zhang, C. et al. Chung, H. et al.

Perry, R. P. & Kelley, D. E. Existence of methylated messenger RNA in mouse L cells. Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases. PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator. Increasing evidence suggests that RNA modification pathways are also misregulated in human cancers and may be ideal targets of cancer therapy. Kim JH, Bogner PN, Baek SH, et al. Paris, J. et al. Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases. Park MH, Jo M, Kim YR, Lee CK, Hong JT. Identification and molecular characterization of cellular factors required for glucocorticoid receptor-mediated mRNA decay. Jonkhout, N. et al.

& Nam, Y.
and T.K contributed equally to writing the article and to reviewing and editing the manuscript.T.K. Amin, E. M. et al. In many cases the same pri-miRNA can be a primary transcript for mRNA and other non-coding RNAs.(snRNA). The authors declare that they have no conflict of interest.Boo, S.H., Kim, Y.K. Sung Ho Boo and … However, emerging studies in We use cookies to help provide and enhance our service and tailor content and ads. Ishizuka, J. J. et al. Bohnsack, K., Höbartner, C. & Bohnsack, M. Eukaryotic 5-methylcytosine (m5C) RNA methyltransferases: mechanisms, cellular functions, and links to disease. The role of poly(A) in the translationand stabilityof mRNA IntroductionA.

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.


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