Zingaretti LM, Gezan SA, Ferrão LF, Osorio LF, Monfort A, Muñoz PR, Whitaker VM, Pérez-Enciso M. Exploring deep learning for complex trait genomic prediction in Polyploid outcrossing species. 1 for three outputs, d inputs (not only 8), N1 hidden neurons (units) in hidden layer 1, N2 hidden units in hidden layer 2, N3 hidden units in hidden layer 3, N4 hidden units in hidden layer 4, and three neurons in the output layers are given by the following eqs. This is the concept we think of as “General AI” — fabulous machines that have all our senses (maybe even more), all our reason, and think just like we do. On to the next chapter for crop breeding: convergence with data science. Often the results are mixed below the –perhaps exaggerated– expectations for datasets with relatively small numbers of individuals [45]. presum % > % group_by(Environment, Trait) % > %. Cardiovascular diseases kill approximately 17 million people globally every year, and they mainly exhibit as myocardial infarctions and heart failures. Google ScholarÂ. Pook, T., Freudentha, J., Korte, A., Simianer, H. (2020). Corresponding authors also revised and put together tables and figures tables and figures on the various revised versions of the review and checked out the correct citations of all 100 references. Detection and analysis of wheat spikes using convolutional neural networks. 2016;17:1–16. AFS was a file system and sharing platform that allowed users to access and distribute stored content. The final output is then determined by the total of those weightings. https://doi.org/10.1186/s12864-020-07319-x, DOI: https://doi.org/10.1186/s12864-020-07319-x. Môro GV, Santos MF, de Souza Júnior CL. In 2016, a robot player beat a human player in the famed game AlphaGo, which was considered an almost impossible task. 2017;835:12003. Front Genet. California Privacy Statement, This activation function has the Dying ReLU problem that occurs when inputs approach zero, or are negative, that causes the gradient of the function becomes zero; thus under these circumstances, the network cannot perform backpropagation and cannot learn efficiently [47, 48]. Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties. An experimental validation of genomic selection in octoploid strawberry. This means that it is feasible to develop systems that can automatically discover plausible models from data, and explain what they discovered; these models should be able, not only to make good predictions, but also to test hypotheses and in this way unravel the complex biological systems that give rise to the phenomenon under study. 2011;12(1):186. Bellot et al. While linear and non-linear algorithms performed best for a similar number of traits, the performance of non-linear algorithms varied more between traits than that of linear algorithms (Table 3B). To implement the hyper-parameter tuning process, dividing the data at hand into three mutually exclusive parts (Fig. 4) is recommended [55]: a training set (for training the algorithm to learn the learnable parameters). [72], in a study conducted on complex human traits (height and heel bone mineral density), compared the predictive performance of MLP and CNN with that of Bayesian linear regressions across sets of SNPs (from 10 k to 50 k, with k = 1000) that were preselected using single-marker regression analyses. Pearson prentice hall, Third Edition, New York, USA; 2009. One approach for building the training-tuning-testing set is to use conventional k fold (or random partition) cross-validation where k-1 folds are used for the training (outer training) and the remaining fold for testing. READ PAPER. This type of neural network can be monolayer or multilayer. Trends Plant Sci. Amara J, et al. However, these networks are prone to overfitting. 2013;194(3):573–96. Abelardo Montesinos-López or José Crossa. [61] found that the MLP across the six neurons used in the implementation outperformed the BRR by 52% (with pedigree) and 10% (with markers) in fat yield, 33% (with pedigree) and 16% (with markers) in milk yield, and 82% (with pedigree) and 8% (with markers) in protein yield. Proc IEEE. Annu Rev Anim Biosci. Alipanahi B, Delong A, Weirauch MT, Frey BJ. First, the convolution operation is applied to the input, followed by a nonlinear transformation (like Linear, ReLU, hyperbolic tangent, or another activation function); then the pooling operation is applied. However, for the output layer, we need to use activation functions (f5t) according to the type of response variable (for example, linear for continuous outcomes, sigmoid for binary outcomes, softmax for categorical outcomes and exponential for count data). Using nine datasets of maize and wheat, Montesinos-López et al. In addition, there are medical applications for identifying and classifying cancer or dermatology problems, among others. Nature. These authors concluded that the three models had very similar overall prediction accuracy, with only slight superiority of RKHS and RBFNN over the additive Bayesian LASSO model. 2019;10:553. We found no relevant differences in terms of prediction performance between conventional genome-based prediction models and DL models, since in 11 out of 23 studied papers (see Table 1), DL was best in terms of prediction performance taking into account the genotype by interaction term; however, when ignoring the genotype by environment interaction, DL was better in 13 out of 21 papers. [6] performed a comparative study between the MLP, RKHS regression and BL regression for 21 environment-trait combinations measured in 300 tropical inbred lines. Pérez-Rodríguez P, Flores-Galarza S, Vaquera-Huerta H, Montesinos-López OA, del Valle-Paniagua DH, Crossa J. Genome-based prediction of Bayesian linear and non-linear regression models for ordinal data. The publications are ordered by year, and for each publication, the Table gives the crop in which DL was applied, the DL topology used, the response variable used and the conventional genomic prediction models with which the DL model was compared. For this reason, this predictive methodology has been adopted for crop improvement in many crops and countries. Artificial intelligence (AI) is the development of computer systems that are able to perform tasks that normally require human intelligence. Kononenko I, Kukar M. Machine Learning and Data Mining: Introduction to Principles and Algorithms. 2018;115(18):4613. Thus, deep neural networks (DNN) can be seen as directed graphs whose nodes correspond to neurons and whose edges correspond to the links between them. volume 22, Article number: 19 (2021) PubMed  2019;2019(10):621. But they are not the same things. Article  Rachmatia H, Kusuma WA, Hasibuan LS. Math Control Signal Syst. Pérez-Rodríguez et al. ###########Fit of the model for each values of the grid#################. de México, Mexico, Paulino Pérez-Rodríguez & José Crossa, Department of Animal Production (DPA), Universidad Nacional Agraria La Molina, Av. pheno <− data.frame (GID = phenoMaizeToy[, 1], Env= phenoMaizeToy[, 2]. There are also successful applications of DL for high-throughput plant phenotyping [44]; a complete review of these applications is provided by Jiang and Li [44]. DL with univariate or multivariate outcomes can be implemented in the Keras library as front-end and Tensorflow as back-end [48] in a very user-friendly way. She’s also the author of four bestselling Vietnamese books. However, this task of DL (i.e., selecting the best candidate individuals in breeding programs) requires not only larger datasets with higher data quality, but also the ability to design appropriate DL topologies that can combine and exploit all the available collected data. On the representation of continuous functions of several variables by superposition of continuous functions of one variable and addition. https://doi.org/10.1038/hdy.2013.16. CAS  The best prediction performance with the interaction term (I) was with the TGBLUP model, with gains of 17.15% (DTHD), 16.11% (DTMT) and 4.64% (Height) compared to the SVM method, and gains of 10.70% (DTHD), 8.20% (DTMT) and 3.11% (Height) compared to the DL model. Comparison of representative and custom methods of generating core subsets of a carrot germplasm collection. Google ScholarÂ. The rectifier linear unit (ReLU) activation function is flat below some thresholds and then linear. Some say AlphaFold 2 may do for structural proteomics what DNA sequencing did for genomics. A deep convolutional neural network approach for predicting phenotypes from genotypes. Crop Sci. 2018;38:75. To help you find a topic that can hold your interest, Science Buddies has also developed the Topic Selection Wizard.It will help you focus on an area of science that's best for you without having to read through every project one by one! 2009;183(1):347–63. With Deep learning’s help, AI may even get to that science fiction state we’ve so long imagined. For example, Vivek et al. Article  Genetics. Convolution is a type of linear mathematical operation that is performed on two matrices to produce a third one that is usually interpreted as a filtered version of one of the original matrices [48]; the output of this operation is a matrix called feature map. (1–5): where f1, f2, f3, f4 and f5t are activation functions for the first, second, third, fourth, and output layers, respectively. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 7/18: Our paper on designing fair AI is published in Nature. Gianola et al. [80] also compared conventional genomic prediction models (BL, BRR, BRR-GM and RKHS) with CNNs (a type of DL model). According to Van Vleck [29], the standard additive genetic effect model is the aforementioned GBLUP for which the variance components have to be estimated and the mixed model equations of Henderson [30] have to be solved. 2016;6:2611–6. J Exp Bot. A five-layer feedforward deep neural network with one input layer, four hidden layers and one output layer. Deep learning is a disruptive technology that has immense potential for applications in any area of predictive data science. Comput Electron Agric. Min_MSE = model_fit_Final$metrics$val_mean_squared_error[No.Epoch_Min]. PubMed  Front Plant Sci. Cybenko G. Approximations by superpositions of sigmoidal functions. $$ {V}_{1j}={f}_1\left(\sum \limits_{i=1}^d{w}_{ji}^{(1)}{x}_i+{b}_{j1}\right)\ \mathrm{for}\ j=1,\dots, {N}_1 $$, $$ {V}_{2k}={f}_2\left(\sum \limits_{j=1}^{N_1}{w}_{kj}^{(2)}{V}_{1j}+{b}_{k2}\right)\ \mathrm{for}\ k=1,\dots, {N}_2 $$, $$ {V}_{3l}={f}_3\left(\sum \limits_{k=1}^{N_2}{w}_{lk}^{(3)}{V}_{2k}+{b}_{l3}\right)\ \mathrm{for}\ l=1,\dots, {N}_3 $$, $$ {V}_{4m}={f}_4\left(\sum \limits_{l=1}^{N_3}{w}_{ml}^{(4)}{V}_{3l}+{b}_{m4}\right)\ \mathrm{for}\ m=1,\dots, {N}_4 $$, $$ {y}_t={f}_{5t}\left(\sum \limits_{m=1}^{N_4}{w}_{tm}^{(5)}{V}_{4m}+{b}_{t5}\right)\ \mathrm{for}\ t=1,2,3 $$, \( {w}_{ji}^{(1)},{w}_{kj}^{(2)},{w}_{lk}^{(3)},{w}_{ml}^{(4)},{w}_{tm}^{(5)}\Big) \), \( g(z)=\left\{\begin{array}{c}z\ ifz>0\\ {}\alpha z\ otherwise\end{array}\right. https://doi.org/10.1186/s12864-016-2553-1. [74], in a study of durum wheat where they compared GBLUP, univariate deep learning (UDL) and multi-trait deep learning (MTDL), found that when the interaction term (I) was taken into account, the best predictions in terms of mean arctangent absolute percentage error (MAAPE) across trait-environment combinations were observed under the GBLUP (MAAPE = 0.0714) model and the worst under the UDL (MAAPE = 0.1303) model, and the second best under the MTDL (MAAPE = 0.094) method. Dear Twitpic Community - thank you for all the wonderful photos you have taken over the years. Heart failure (HF) occurs when the heart cannot pump enough blood to meet the needs of the body.Available electronic medical records of patients quantify symptoms, body features, and clinical laboratory test values, which can be used to … The prediction performance in GS is affected by the size of the training dataset, the number of markers, the heritability, the genetic architecture of the target trait, the degree of correlation between the training and testing set, etc. Mastrodomenico AT, Bohn MO, Lipka AE, Below FE. ); (d) there is much empirical evidence that the larger the dataset, the better the performance of DL models, which offers many opportunities to design specific topologies (deep neural networks) to deal with any type of data in a better way than current models used in GS, because DL models with topologies like CNN can very efficiently capture the correlation (special structure) between adjacent input variables, that is, linkage disequilibrium between nearby SNPs; (f) some DL topologies like CNN have the capability to significantly reduce the number of parameters (number of operations) that need to be estimated because CNN allows sharing parameters and performing data compression (using the pooling operation) without the need to estimate more parameters; and (g) the modeling paradigm of DL is closer to the complex systems that give rise to the observed phenotypic values of some traits. With this convolutional layer, we significantly reduce the size of the input without relevant loss of information. For soybean [Glycine max (L.) Merr. NPTEL provides E-learning through online Web and Video courses various streams. This activation function is one of the most popular in DL applications for capturing nonlinear patterns in hidden layers [47, 48]. 1). Nauk SSSR. #########Matrices for saving the output of inner CV#######################. Prediction of total genetic value using genome-wide dense marker maps. The mean squared error was reduced by at least 6.5% in the simulated data and by at least 1% in the real data. [67] to predict phenotypes from genotypes in wheat and found that the DL method outperformed the GBLUP method. However, when the dataset is small, this process needs to be replicated, and the average of the predictions in the testing set of all these replications should be reported as the prediction performance. rownames (phenoMaizeToy)=1:nrow (phenoMaizeToy). Shalev-Shwartz B-D. Understanding machine learning: from theory to algorithms. G3-Genes-Genom Genet. CNN use images as input and take advantage of the grid structure of the data. Download PDF. A guide on deep learning for complex trait genomic prediction. summarise (MSE = mean((Predicted-Observed)^2). 9/18: Excited to receive a NIH Center for Excellence in Genomics and a NIH R21. Waldmann P. Approximate Bayesian neural networks in genomicprediction. The adjective “deep” is related to the way knowledge is acquired [36] through successive layers of representations. Montesinos-López OA, Montesinos-López A, Tuberosa R, Maccaferri M, Sciara G, Ammar K, Crossa J. Multi-trait, multi-environment genomic prediction of durum wheat with genomic best linear unbiased predictor and deep learning methods. Still, a small heretical research group led by Geoffrey Hinton at the University of Toronto kept at it, finally parallelizing the algorithms for supercomputers to run and proving the concept, but it wasn’t until GPUs were deployed in the effort that the promise was realized. Median_MSE_Inner = apply (Tab_pred_MSE,2,median). There is a widespread sense that implementing DL into a breeding pipeline is not straightforward without a strong statistical/computing background associated to the use of super computers - both limiting factors for some modest breeding programs. Here, only one input variable is presented to the input units, the feedforward flow is computed, and the outputs are feedback as auxiliary inputs. The input is passed to the neurons in the first hidden layer, and then each hidden neuron produces an output that is used as an input for each of the neurons in the second hidden layer. For this reason, CNN include fewer parameters to be determined in the learning process, that is, at most half of the parameters that are needed by a feedforward deep network (as in Fig. DeepCount: in-field automatic quantification of wheat spikes using simple linear iterative clustering and deep convolutional neural networks. BMC Genomics 22, 19 (2021). [4] has become an established methodology in breeding. However, when the interaction term was ignored, the best predictions were observed under the GBLUP (MAAPE = 0.0745) method and the MTDL (MAAPE = 0.0726) model, and the worst under the UDL (MAAPE = 0.1156) model; non-relevant differences were observed in the predictions between the GBLUP and MTDL. 1), recurrent neural networks and convolutional neural networks. 2012;2(12):1595–605. Habier D, Fernando RL, Kizilkaya K, Garrick DJ. In Holstein-Friesian bulls, the Pearson’s correlations across traits were 0.59, 0.51 and 0.57 in the GBLUP, MLP normal and MLP best, respectively, while in the Holstein-Friesian cows, the average Pearson’s correlations across traits were 0.46 (GBLUP), 0.39 (MLP normal) and 0.47 (MLP best). https://doi.org/10.1109/CVPRW.2018.00222. Then if the sample size is small using the outer training set, the DL model is fitted again with the optimal hyper-parameter. Because DL has many advantages, it is extremely popular and its applications are everywhere. Also, Fig. 3 indicates that depending on the complexity of the input (images), the number of convolutional layers can be more than one to be able to capture low-level details with more precision. It is important to apply DL to large training-testing data sets. Context-specific Genomic Selection Strategies Outperform Phenotypic Selection for Soybean Quantitative Traits in the Progeny Row Stage. [73] performed a benchmark study to compare univariate deep learning (DL), the support vector machine and the conventional Bayesian threshold best linear unbiased prediction (TGBLUP). Wiggans GR, Cole JB, Hubbard SM, Sonstegard TS. Figure 2a illustrates an example of a recurrent two-layer neural network. A primer on neural network models for natural language processing. PubMed  Bellot P, de los Campos, G., Pérez-Enciso, M. Can deep learning improve genomic prediction of complex human traits? Part of Gianola D, Okut H, Weigel KA, Rosa GJ. The DL methods are nonparametric models providing flexibility to adapt to complicated associations between data and output with the ability to adapt to very complex patterns. For height and heel bone mineral density, all methods performed similarly, but in general CNN was the worst. Boca Raton: CRC Press; 1993. BMC Genet. They had been around since the earliest days of AI, and had produced very little in the way of “intelligence.” The problem was even the most basic neural networks were very computationally intensive, it just wasn’t a practical approach. González-Camacho JM, de los Campos, G., Pérez, P., Gianola, D., Cairns, J.E., Mahuku, G., et al. da Silva, M.S., de Oliveira, L.A., Aguilar-Vildoso, C.I. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. to be able to address long-standing problems in GS in terms of prediction efficiency. Montesinos-López OA, Montesinos-López JC, Salazar-Carrillo E, Barrón-López JA, Montesinos-López A, Crossa J. What it needs is training. In strawberry and blueberry, Zingaretti et al. Bernardo R. Molecular markers and selection for complex traits in plants: learning from the last 20 years. Driverless cars, better preventive healthcare, even better movie recommendations, are all here today or on the horizon. Frankly, until 2012, it was a bit of both. 2012;125:759–71. Deep kernel and deep learning for genome-based prediction of single traits in multienvironment breeding trials. Y < - as.matrix (phenoMaizeToy[, −c(1, 2)]). They found that in general the MLP model with 20 hidden layers outperformed conventional genomic prediction models (LR and RT) and also the MLP model with only one hidden layer (SNN) (Table 3A), but the best performance was observed in the GY trait. Download. 37 Full PDFs related to this paper. https://doi.org/10.1146/annurev-animal-031412-103705. Euphytica. https://doi.org/10.1007/s00425-018-2976-9. This leads to a different set of hidden unit activations, new output activations, and so on. CAS  Andrew File System (AFS) ended service on January 1, 2021. Pook et al. For example, before 2015, humans were better than artificial machines at classifying images and solving many problems of computer vision, but now machines have surpassed the classification ability of humans, which was considered impossible only some years ago. DL has been especially successful when applied to regulatory genomics, by using architectures directly adapted from modern computer vision and natural language processing applications. Deep Learning: A Hands-On Approach Course, School of Data Science, School of Engineering and Applied Science Articulate concepts, algorithms, and tools to build intelligent systems. Tab_pred_Drop = matrix (NA,ncol = length (Stage[,1]), nrow = nCVI). Beyond making predictions, deep learning could become a powerful tool for synthetic biology by learning to automatically generate new DNA sequences and new proteins with desirable properties. The first vertical sub-panel corresponds to the model with genotype × environment interaction (I), and the second vertical sub-panel corresponds to the same model but without genotype × environment interaction (WI) (Montesinos-López et al., 2018a). A neural network for modeling ordinal data using a data augmentation approach was proposed by Pérez-Rodríguez et al. https://doi.org/10.2135/cropsci1994.0011183X003400010003x. in the same model, which is not possible with most machine learning and statistical learning methods; (c) frameworks for DL are very flexible because their implementation allows training models with continuous, binary, categorical and count outcomes, with many hidden layers (1,2, …), many types of activation functions (RELU, leakyRELU, sigmoid, etc. Below is a list of the 1429 science fair project ideas on our site. They found in real datasets that when averaged across traits in the strawberry species, prediction accuracies in terms of average Pearson’s correlation were 0.43 (BL), 0.43 (BRR), 0.44 (BRR-GM), 0.44 (RKHS), and 0.44 (CNN). The authors found in general terms that CNN performance was competitive with that of linear models, but they did not find any case where DL outperformed the linear model by a sizable margin (Table 2B). DL methods have also made accurate predictions of single-cell DNA methylation states [42]. It is important to point out that in each of the hidden layers, we attained a weighted sum of the inputs and weights (including the intercept), which is called the net input, to which a transformation called activation function is applied to produce the output of each hidden neuron. Comparison of genome-wide and phenotypic selection indices in maize. Every neuron of layer i is connected only to neurons of layer i + 1, and all the connection edges can have different weights. PubMed Central  Over the past few years AI has exploded, and especially since 2015. model_fit_Final<−model_Final % > % fit(. Waldmann [68] found that the resulting testing set MSE on the simulated TLMAS2010 data were 82.69, 88.42, and 89.22 for MLP, GBLUP, and BL, respectively. Gesellschaft für Informatik. Uzal LC, Grinblat GL, Namías R, et al. The max pooling operation summarizes the input as the maximum within a rectangular neighborhood, but does not introduce any new parameters to the CNN; for this reason, max pooling performs dimensional reduction and de-noising. Finally, with these estimated parameters (weights and bias), the predictions for the testing set are obtained. The main difference between DL methods and conventional statistical learning methods is that DL methods are nonparametric models providing tremendous flexibility to adapt to complicated associations between data and output. Plant Genome. 2020;52:12. https://doi.org/10.1186/s12711-020-00531-z. No.Epoch_Min = length (model_fit_Final$metrics$val_mean_squared_error). Google’s AlphaGo learned the game, and trained for its Go match — it tuned its neural network — by playing against itself over and over and over. PLoS One. Manage cookies/Do not sell my data we use in the preference centre. Jiang Y, Li C. Convolutional neural networks for image-based high-throughput plant Phenotyping: A review. 2015;33:831–8. Thanks to the availability of more frameworks for implementing DL algorithms, the democratization of this tool will continue in the coming years since every day there are more user-friendly and open-source frameworks that, in a more automatic way and with only some lines of code, allow the straightforward implementation of sophisticated DL models in any domain of science. The same behavior is observed in Table 4B under the MSE metrics, where we can see that the deep learning models were the best, but without the genotype × environment interaction, the NDNN models were slightly better than the PDNN models. 2019;9(11):3691–702. PubMed Central  There’s a reason computer vision and image detection didn’t come close to rivaling humans until very recently, it was too brittle and too prone to error. 2018;9:343. This process is repeated in each fold and the average prediction performance of the k testing set is reported as prediction performance. [64] studied and compared two classifiers, MLP and probabilistic neural network (PNN). Dobrescu A, Valerio Giuffrida M, Tsaftaris SA. Google ScholarÂ. In general, these authors found that linear Bayesian models were better than convolutional neural networks for the full additive architecture, whereas the opposite was observed under strong epistasis. Ultimately, the activations stabilize, and the final output values are used for predictions. Hort Res. ZEG < - model.matrix(~ 0 + as.factor (phenoMaizeToy$Line):as.factor (phenoMaizeToy$Env)). Neural Netw. Frontiers. Article  Accelerating the domestication of forest trees in a changing world. https://doi.org/10.1371/journal.pone.0184198. Today, image recognition by machines trained via deep learning in some scenarios is better than humans, and that ranges from cats to identifying indicators for cancer in blood and tumors in MRI scans. PubMed  https://doi.org/10.1016/j.tplants.2018.07.004. Consequently, many genomic prediction methods have been proposed. For these reasons, the incorporation of DL for classical breeding pipelines is in progress and some uses of DL are given next: 1) for the prediction of parental combinations, which is critical for choosing superior combinational homozygous parental lines in F1-hybrid breeding programs [84], 2) for modelling and predicting quantitative characteristics, for example, to perform image-based ear counting of wheat with high level of robustness, without considering variables, such as growth stage and weather conditions [85], 3) for genetic diversity and genotype classification, for example, in Cinnamomum osmophloeum Kanehira (Lauraceae), DL was applied to differentiate between morphologically similar species [86], and 4) for genomic selection (see Table 1). Genetics. An explainable deep machine vision framework for plant stress phenotyping. Activation functions are crucial in DL models. [43] also used the TLMAS2010 data from the Waldmann et al. 2013;8:e61318. 3 also shows that after the convolutional layers, the input of the image is flattened (flattening layer), and finally, a feedforward deep network is applied to exploit the high-level features learned from input images to predict the response variables of interest (Fig. Z.E- model.matrix(~0+as.factor (phenoMaizeToy$Env)). Today, genomic selection (GS), proposed by Bernardo [3] and Meuwissen et al. Crop Sci. Van Vleck LD. Genet Sel Evol. Liu Y, Wang D, He F, Wang J, Joshi T, Xu D. Phenotype prediction and genome-wide association study using deep convolutional neural network of soybean.
Jeu Switch Bébé, Expliquer La Dissolution D'un Composé Ionique, Bouna Sarr Transfert Prix, Vector Map South America, Crochet Pour Rayonnage, L'enfance En Arabe, Location Jeux De Société Rennes, Prise Coaxiale Internet,